ZHOU Qingfa

Source:理学院英文网  Time:2017-12-25  Page Views:11








Qingfa Zhou, Associate Professor of Organic Chemistry

Education  

 2003—2008     Ph.D., University of Science and Technology of China Organic Chemistry Advisor: Prof. Song Xue and Prof. Qingxiang Guo  

1995—1999     B.S.,  An Hui Normal University  Chemistry


Position

2011—Present   China Pharmaceutical University  Associate Professor

2008 —2011    China Pharmaceutical University  Lecturer


Research Interests

Synthetic Organic Chemistry: developing new synthetic strategies and synthesis of natural products.

Medicinal Chemistry:  Designing and synthesizing the potential drug molecule.


Research Experience

National Natural Science Foundation of China (Grant No. 21102179 and 21572271); Fundamental Research Funds for the Central Universities (No. JKZ2011011).



Recent Publications

  1. Zhusheng Huang, Yishu Bao, Yu Zhang, Fulai Yang, Tao Lu, and Qingfa Zhou*. “Hydroxy-Assisted Regio- and Stereoselective Synthesis of Functionalized 4-Methylenepyrrolidine Derivatives via Phosphine-Catalyzed [3 + 2] Cycloaddition of Allenoates with o-Hydroxyaryl Azomethine YlidesJ. Org. Chem. 2017, 82, 12726−12734

  2. Shuang Zhao, Yong Zhu, Yichao Wu, Tao Lu, Qingfa Zhou*. “Phosphine-Catalyzed Domino Reactions of Allenoates with N-Hydroxyphthalimides: Direct Method to 3a-Hydroxyisoxazolo[3,2-a]isoindol-8(3 aH)-one Derivatives”ChemistrySelect 2017,2,1700-1704.

  3. Zhusheng Huang, Xiuqin Yang, Fulai Yang, Tao Lu, and Qingfa Zhou*. “Phosphine-Catalyzed Domino β/γ-Additions of Benzofuranones with Allenoates: A Method for Unsymmetrical 3,3-Disubstituted Benzofuranones”Org. Lett. 2017, 19, 3524-3527.

  4. Zhusheng Huang, Qingqing Chen, Xiuqin Yang, Yang Liu, Li Zhang, Tao Lu* and Qingfa Zhou*. “Phosphine-mediated domino reactions of phthalimidomalonates with allenoates or but-2-ynoate: facile entry into highly functionalized pyrroloisoindolinone derivatives” Org. Chem. Front. 2017, 4, 967-971.

  5. Li Zhang, Beichen Zhang, Teng Jiang, Tao Lu* and Qingfa Zhou*. “Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives” Org. Chem. Front. 2017, 4, 119-123.

  6. Qing-Fa Zhou, Kui Zhang, Lingchao Cai, and Ohyun Kwon*. “Phosphine-Catalyzed Intramolecular Cyclizations of α Nitroethylallenoates Forming (Z) Furanone Oximes” Org. Lett. 2016, 18, 2954-2957.

  7. Qing-Fa Zhou*, Fei-Fei Ge, Qing-Qing Chen, Tao Lu*. “Construction of pyrazolo[5,1-a]isoindol-8(3aH)-one derivatives via phosphine-catalyzed cyclization of electron-deficient alkynes and N-amino substituted pathalimide” RSC Adv., 2016, 6, 1395-1402.

  8. Qingqing Chen, Kaixuan Li, Tao Lu* and Qingfa Zhou*. “Phosphine-catalyzed domino reactions of alkynyl ketones with sulfonylhydrazones: construction of diverse pyrazoloquinazoline derivatives” RSC Adv., 2016, 6, 24792–24796.

  9. Zhimin Zhang, Li Zhang, Qingqing Chen, Tao Lu* and Qingfa Zhou*. “Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4+2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes” RSC Adv., 2016, 6, 61680–61685.

  10. Xin Chen, Fei-Fei Ge, Tao Lu*, Qing-Fa Zhou*. “Stereoselective Synthesis of 3-Methyleneisoindolin-1-ones via Base-Catalyzed Intermolecular Reactions of Electron-Deficient Alkynes with N-Hydroxyphthalimides” J. Org. Chem 2015, 80, 3295-3301.

  11. Qing-Fa Zhou, Kui Zhang, Ohyun Kwon*. “Stereoselective syntheses of α, β-unsaturated amino esters through phosphine-catalyzed y-umpolung additions of sulfonamides to y-substituted allenoates” Tetrahedron Lett. 2015, 56, 3273-3276.

  12. Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Yue Wang, Tao Lu*. “Phosphine-Catalyzed [3+2] Annulation of Electron-Deficient Alkynes with N-Hydroxyphthalimide: Synthesis of 3a-Hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones”Adv. Synth. Catal. 2013, 355, 2787-2792.

  13. Qing-Fa Zhou*, Xue-ping Chu, Fei-fei Ge, Li Cheng, Tao Lu*. “Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions” Mol Divers 2013, 17, 563-571.

  14. Chu Xue-Ping, Zhou Qing-Fa*, Zhao Shen, Ge Fei-Fei, Fu Mian, Chen Jia-Peng, Lu Tao*. “Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitor” Chin. Chem. Lett. 2013, 24, 120-122.

  15. Qing Fa Zhou*, Xueping Chu, Weifang Tang, Tao Lu*. “An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate” Tetrahedron 2012, 68, 4152-4158.

  16. Qing Fa Zhou*, Xue Ping Chu, Shen Zhao, Tao Lu, Wei Fang Tang*. “BF3.Et2O promoted conjugate addition of ethanethiol to electron-deficient alkynes” Chin. Chem. Lett. 2012, 23, 639-642.

  17. Zhao Shen, Zhou Qing-Fa*, Liu Jia-Zhi, Tang Wei-Fang, Lu Tao.* “Tributylphosphine-catalyzed reaction of ethanethiol with alkynyl ketones” Chin. Chem. Lett. 2011, 22397-400.

  18. Zhou Qing-Fa, Zhu Yong, Tang Wei-Fang, Lu Tao “NaOH-Catalyzed Michael Addition-Lactionization Reaction of Electron-Deficient Alkynes with N-(diphenylmethylene)glycinates: An Efficient Synthesis of 3-Amino-2-Pyrone Derivatives” Synthesis 2010, 211.

  19. Zhou Qing-Fa, Zhao Sheng, Wang Xun, Lu Tao “Research Progress in the Synthesis of 2-Pyrone Derivatives” Chin. J. Org. Chem. 2010, 30, 1652-1663.

  20. Hu Bin, Zhou Qing-Fa*, Tang Kai, Xue Song* “Synthesis of Trisubstituted-4H-Pyrans via Unexpected Cycloaddition of Aldehydes with Acetylenic Ketones Mediated by DMAP and 2,4-Pentanedione” Lett. in Org. Chem. 2009, 6, 560-563.

  21. Zhou Qing-Fa, Xin Bo-Tao, Lu Tao, Xue Song “DMAP-catalyzed Benzannulation Reaction of Aromatic 1,3-Diketones with 3-Butyn-2-one” Chin. J. Org. Chem. 2009, 29, 1462-1465.

  22. Zhou Qing-Fa, Wu Quan-Ping; Xue Song “Et3N-Promoted reaction of acetylenic ketones with N-(diphenylmethylene)- glycinates: an efficient synthesis of α,β-dehydroamino acid derivatives”, Tetrahedron Lett. 2008,49,7027.

  23. Zhou Qing-Fa, Yang Fei, Guo Qing-Xiang, Xue Song “A New Organocatalytic Process of Cyclotrimerization of Acetylenic Ketones Mediated by 2,4-pentanedione”Synlett 2007, 215.

  24. Zhou Qing-Fa, Yang Fei, Guo Qing-Xiang, Xue Song “Unexpected DMAP-Catalyzed Highly Regioselective Benzenanution of Ethyl Propiolate with β-Dicarbonyl Moities”Synlett 2007, 2073.

  25. Zhou Qing-Fa, Yang Fei, Guo Qing-Xiang, Xue Song. “Triphenylphosphine Catalyzed Isomerization of Alkynyl Ketones in Water”, Chin. Chem. Lett. 2007, 8, 1029.

  26. Xue Song*, Zhou Qing-Fa, Li Le-Zheng, Guo Qing-Xiang “Triphenylphosphine-Catalyzed Reaction of Aldehydes and Acetylenic Ketones with 1,3-Dicarbonyl Moieties: Synthesis of Multi-Carbonyl Compounds”Synlett 2005, 2990.

  27. Xue Song*, Zhou Qing-Fa, Zheng Xiao-Qi “α-Addition of 1,3-Dicarbonyl Compounds to Acetylenic Ketones Catalyzed by Triphenylphosphine”Synth. Commun. 2005, 35, 3027.