ZHAO Peixuan

Source:理学院英文网  Time:2017-12-26  Page Views:11

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Zhao, PEIXUAN

Lecturer of Analytical Chemistry

School of Sciences

Phone: 86-15996410994

Email: ziyouapi@163.com

Research Summary

Dr. Zhao’s research focuses on affinity chromatography, including the design of novel affinity chromatography materials and their applications in bioanalysis.

1. Design of novel affinity materials for proteome analysis, such as immobilized metal ion affinity chromatography(IMAC) for phosphopeptide enrichment and endotoxin removal, boronateaffinity chromatography (BAC) for specific isolation and enrichment of cis-diol-containing biomolecules (carbohydrates, glycoproteins, RNA,nucleosides and endotoxins), etc.

2. Molecular recognition of biomarkers (i.e. phosphoproteins, glycoproteins) in bodily fluids by means of molecular imprinting.

3. Ultrasensitive detection of glycoproteins using surface-enhanced Raman scattering (SERS).

4. Solid-phase labeling of saccharides within mesoporous materials.

5. Stimuli-responsive materials for drug delivery.


Education

2007–2012Ph.D. in Department of Analytical Chemistry,College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China.

2003–2007   B.S. in Department of Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng475001, Henan, China.


Awards and Honors

2013    Union activist, China Pharmaceutical University


Publications

[1] Pei-Xuan Zhao, Xiao-Feng Guo, Hong Wang, Chu-Bo Qi, He-Shun Xia, Hua-Shan Zhang. Zirconium arsenate-modified silica nanoparticles for specific capture of phosphopeptides and direct analysis by matrix-assisted laser desorption/ionization mass spectrometry. Anal. Bioanal. Chem. 2012, 402, 1041–1056.

[2] Pei-Xuan Zhao, Yong Zhao, Xiao-Feng Guo, Hong Wang, Hua-Shan Zhang. Isolation of phosphopeptides using zirconium-chlorophosphonazo chelate-modied silica nanoparticles. J. Chromatogr. A 2011, 1218, 2528–2539.

[3] Xianghua Pan, Yang Chen, Peixuan Zhao, Daojin Li, Zhen Liu. Highly efficient solid-phase labeling of saccharides within boronic acid functionalized mesoporous silica nanoparticles. Angew. Chem. Int. Ed. 2015, 54, 6173–6176.

[4] Xiao-Feng Guo, Pei-Xuan Zhao, HongWang, Hua-Shan Zhang. Simple  and  rapid  determination  of  thiol  compounds  by  HPLC  and  uorescence detection with 1,3,5,7-tetramethyl-8-phenyl-(2-maleimide) diuoroboradiaza-s-indacene. J. Chromatogr. B 2011, 879, 3932–3936.

[5] Pei-Xuan Zhao, Xiao-Feng Guo, Hui-Juan Zhang, Hong Wang. Advances in new materials for enrichment, separation and MS analysis of protein phosphorylation. J. Anal. Sci. 2013, 29, 127–134.(In Chinese)