ZHOU Qingfa

Source:理学院英文网  Time:2017-12-25  Page Views:11

Qingfa Zhou, Associate Professor of Organic Chemistry


 2003—2008     Ph.D., University of Science and Technology of China Organic Chemistry Advisor: Prof. Song Xue and Prof. Qingxiang Guo  

1995—1999     B.S.,  An Hui Normal University  Chemistry


2011—Present   China Pharmaceutical University  Associate Professor

2008 —2011    China Pharmaceutical University  Lecturer

Research Interests

Synthetic Organic Chemistry: developing new synthetic strategies and synthesis of natural products.

Medicinal Chemistry:  Designing and synthesizing the potential drug molecule.

Research Experience

National Natural Science Foundation of China (Grant No. 21102179 and 21572271); Fundamental Research Funds for the Central Universities (No. JKZ2011011).

Recent Publications

  1. Zhusheng Huang, Yishu Bao, Yu Zhang, Fulai Yang, Tao Lu, and Qingfa Zhou*. “Hydroxy-Assisted Regio- and Stereoselective Synthesis of Functionalized 4-Methylenepyrrolidine Derivatives via Phosphine-Catalyzed [3 + 2] Cycloaddition of Allenoates with o-Hydroxyaryl Azomethine YlidesJ. Org. Chem. 2017, 82, 12726−12734

  2. Shuang Zhao, Yong Zhu, Yichao Wu, Tao Lu, Qingfa Zhou*. “Phosphine-Catalyzed Domino Reactions of Allenoates with N-Hydroxyphthalimides: Direct Method to 3a-Hydroxyisoxazolo[3,2-a]isoindol-8(3 aH)-one Derivatives”ChemistrySelect 2017,2,1700-1704.

  3. Zhusheng Huang, Xiuqin Yang, Fulai Yang, Tao Lu, and Qingfa Zhou*. “Phosphine-Catalyzed Domino β/γ-Additions of Benzofuranones with Allenoates: A Method for Unsymmetrical 3,3-Disubstituted Benzofuranones”Org. Lett. 2017, 19, 3524-3527.

  4. Zhusheng Huang, Qingqing Chen, Xiuqin Yang, Yang Liu, Li Zhang, Tao Lu* and Qingfa Zhou*. “Phosphine-mediated domino reactions of phthalimidomalonates with allenoates or but-2-ynoate: facile entry into highly functionalized pyrroloisoindolinone derivatives” Org. Chem. Front. 2017, 4, 967-971.

  5. Li Zhang, Beichen Zhang, Teng Jiang, Tao Lu* and Qingfa Zhou*. “Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives” Org. Chem. Front. 2017, 4, 119-123.

  6. Qing-Fa Zhou, Kui Zhang, Lingchao Cai, and Ohyun Kwon*. “Phosphine-Catalyzed Intramolecular Cyclizations of α Nitroethylallenoates Forming (Z) Furanone Oximes” Org. Lett. 2016, 18, 2954-2957.

  7. Qing-Fa Zhou*, Fei-Fei Ge, Qing-Qing Chen, Tao Lu*. “Construction of pyrazolo[5,1-a]isoindol-8(3aH)-one derivatives via phosphine-catalyzed cyclization of electron-deficient alkynes and N-amino substituted pathalimide” RSC Adv., 2016, 6, 1395-1402.

  8. Qingqing Chen, Kaixuan Li, Tao Lu* and Qingfa Zhou*. “Phosphine-catalyzed domino reactions of alkynyl ketones with sulfonylhydrazones: construction of diverse pyrazoloquinazoline derivatives” RSC Adv., 2016, 6, 24792–24796.

  9. Zhimin Zhang, Li Zhang, Qingqing Chen, Tao Lu* and Qingfa Zhou*. “Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4+2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes” RSC Adv., 2016, 6, 61680–61685.

  10. Xin Chen, Fei-Fei Ge, Tao Lu*, Qing-Fa Zhou*. “Stereoselective Synthesis of 3-Methyleneisoindolin-1-ones via Base-Catalyzed Intermolecular Reactions of Electron-Deficient Alkynes with N-Hydroxyphthalimides” J. Org. Chem 2015, 80, 3295-3301.

  11. Qing-Fa Zhou, Kui Zhang, Ohyun Kwon*. “Stereoselective syntheses of α, β-unsaturated amino esters through phosphine-catalyzed y-umpolung additions of sulfonamides to y-substituted allenoates” Tetrahedron Lett. 2015, 56, 3273-3276.

  12. Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Yue Wang, Tao Lu*. “Phosphine-Catalyzed [3+2] Annulation of Electron-Deficient Alkynes with N-Hydroxyphthalimide: Synthesis of 3a-Hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones”Adv. Synth. Catal. 2013, 355, 2787-2792.

  13. Qing-Fa Zhou*, Xue-ping Chu, Fei-fei Ge, Li Cheng, Tao Lu*. “Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions” Mol Divers 2013, 17, 563-571.

  14. Chu Xue-Ping, Zhou Qing-Fa*, Zhao Shen, Ge Fei-Fei, Fu Mian, Chen Jia-Peng, Lu Tao*. “Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitor” Chin. Chem. Lett. 2013, 24, 120-122.

  15. Qing Fa Zhou*, Xueping Chu, Weifang Tang, Tao Lu*. “An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate” Tetrahedron 2012, 68, 4152-4158.

  16. Qing Fa Zhou*, Xue Ping Chu, Shen Zhao, Tao Lu, Wei Fang Tang*. “BF3.Et2O promoted conjugate addition of ethanethiol to electron-deficient alkynes” Chin. Chem. Lett. 2012, 23, 639-642.

  17. Zhao Shen, Zhou Qing-Fa*, Liu Jia-Zhi, Tang Wei-Fang, Lu Tao.* “Tributylphosphine-catalyzed reaction of ethanethiol with alkynyl ketones” Chin. Chem. Lett. 2011, 22397-400.

  18. Zhou Qing-Fa, Zhu Yong, Tang Wei-Fang, Lu Tao “NaOH-Catalyzed Michael Addition-Lactionization Reaction of Electron-Deficient Alkynes with N-(diphenylmethylene)glycinates: An Efficient Synthesis of 3-Amino-2-Pyrone Derivatives” Synthesis 2010, 211.

  19. Zhou Qing-Fa, Zhao Sheng, Wang Xun, Lu Tao “Research Progress in the Synthesis of 2-Pyrone Derivatives” Chin. J. Org. Chem. 2010, 30, 1652-1663.

  20. Hu Bin, Zhou Qing-Fa*, Tang Kai, Xue Song* “Synthesis of Trisubstituted-4H-Pyrans via Unexpected Cycloaddition of Aldehydes with Acetylenic Ketones Mediated by DMAP and 2,4-Pentanedione” Lett. in Org. Chem. 2009, 6, 560-563.

  21. Zhou Qing-Fa, Xin Bo-Tao, Lu Tao, Xue Song “DMAP-catalyzed Benzannulation Reaction of Aromatic 1,3-Diketones with 3-Butyn-2-one” Chin. J. Org. Chem. 2009, 29, 1462-1465.

  22. Zhou Qing-Fa, Wu Quan-Ping; Xue Song “Et3N-Promoted reaction of acetylenic ketones with N-(diphenylmethylene)- glycinates: an efficient synthesis of α,β-dehydroamino acid derivatives”, Tetrahedron Lett. 2008,49,7027.

  23. Zhou Qing-Fa, Yang Fei, Guo Qing-Xiang, Xue Song “A New Organocatalytic Process of Cyclotrimerization of Acetylenic Ketones Mediated by 2,4-pentanedione”Synlett 2007, 215.

  24. Zhou Qing-Fa, Yang Fei, Guo Qing-Xiang, Xue Song “Unexpected DMAP-Catalyzed Highly Regioselective Benzenanution of Ethyl Propiolate with β-Dicarbonyl Moities”Synlett 2007, 2073.

  25. Zhou Qing-Fa, Yang Fei, Guo Qing-Xiang, Xue Song. “Triphenylphosphine Catalyzed Isomerization of Alkynyl Ketones in Water”, Chin. Chem. Lett. 2007, 8, 1029.

  26. Xue Song*, Zhou Qing-Fa, Li Le-Zheng, Guo Qing-Xiang “Triphenylphosphine-Catalyzed Reaction of Aldehydes and Acetylenic Ketones with 1,3-Dicarbonyl Moieties: Synthesis of Multi-Carbonyl Compounds”Synlett 2005, 2990.

  27. Xue Song*, Zhou Qing-Fa, Zheng Xiao-Qi “α-Addition of 1,3-Dicarbonyl Compounds to Acetylenic Ketones Catalyzed by Triphenylphosphine”Synth. Commun. 2005, 35, 3027.