ZHANG Xiaojin

Source:理学院英文网  Time:2017-12-25  Page Views:10


ZHANG, XIAOJIN

Associate Professor of Medicinal Chemistry

School of Science

Phone: 86-13913007140

Email: zxj@cpu.edu.cn

Research Summary

Professor ZHANG’s research interestsinvolvethe design, synthesis, biological evaluation and mechanism study of new drugs. The recent research focuses on two main fields: i) the rational design and discovery of small molecules for the treatment of cancer or anemia by targeting ROS pathway and oxygen-sensing VHL-PHD-HIF system; ii) synthesis, SAR and drugability optimization studies based on natural products, such as bata-lapachone, tanshinone IIA, andgambogic acid.

Education

2012 Ph.D., Medicinal Chemistry, China Pharmaceutical University

2007 B.S., Pharmaceutical Engineering,China Pharmaceutical University

Academic Experience

2015-      Associate Professor of Medicinal Chemistry, China Pharmaceutical University

2002-2015  Assistant Professor of Medicinal Chemistry, China Pharmaceutical University

Awards and Honors

2017       Outstanding Young Scientists Fund, Jiangsu Province

2016       2016’ CPA-Servier Young Investigator Awards in Medicinal Chemistry, CPA & Institut de Recherches Internatinales Servier ( I.R.I.S)

2016       The Second prize of National Science and Technology Progress Award, the State Council of China

2015       The First prize of Science and Technology Progress Award, Jiangsu Province

2014       Outstanding oral presentation for the 9th International Symposium for Chinese Medicinal Chemists, ACS Publication

Selected Publications

  1.  Xian Zhang, Xiang Li, Qidong You,* Xiaojin Zhang.* Prodrug strategy for cancer cell-specific targeting: a recent overview. European Journal of Medicinal Chemistry, 2017, 139, 542-563.

  2.  Jinlei Bian, Xiang Li, Nan Wang, Xingsen Wu, Qidong You,* Xiaojin Zhang.* Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile. European Journal of Medicinal Chemistry,2017, 129, 27-40.

  3. Xiaojin Zhang, Jinlei Bian, Xiang Li, Xingsen Wu, Yanan Dong, Qidong You.* 2-Substituted 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-diones as specific L-shaped NQO1-mediated redox modulators for the treatment of non-small cell lung cancer. European Journal of Medicinal Chemistry, 2017, 138, 616-629.

  4.  Jinlei Bian, Xiang Li,Lili XuNan Wang, Xue Qian, Qidong You,* Xiaojin Zhang.* Affinity-based small fluorescent probe for NAD(P)H:quinone oxidoreductase 1 (NQO1). Design, synthesis and pharmacological evaluation. European Journal of Medicinal Chemistry, 2017, 127, 828-839.

  5. Yue Wu, Zhensheng Jiang, Qidong You,*Xiaojin Zhang.* Application of in-vitro screening methods in hypoxia inducible factor prolyl hydroxylase inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25 (15), 3891-4218.

  6.  XiaoliXu, Yue Wu, Mingyang Hu, Xiang Li, Qichao Bao, Jinlei Bian, Qidong You,* Xiaojin Zhang.* Novel natural-product-like caged xanthones bearing carbamate moiety exhibit antitumor potency and anti-angiogenesis activity in vivo. Scientific Reports, 2016, 6, 35771.

  7.  Xiaoli Xu, Yue Wu, Mingyang Hu, Xiang Li, Congying Gu, Qidong You,* Xiaojin Zhang.* Structure-activity relationship of Garcinia xanthones analogues: potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity. Bioorganic & Medicinal Chemistry, 2016, 24 (19), 4626-4635.

  8.  Yue Wu, Nan Wang, Yonghua Lei, Tianhan Hu, Qidong You,* Xiaojin Zhang.* Small molecular inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy. MedChemComm, 2016, 7 (7), 1259-1452.

  9.  Xiang Li,1 Jinlei Bian,1 Nan Wang, Xue Qian, Jing Gu, Tong Mu, Jun Fan, Xiuwen Yang, Shangzhen Li, Tingting Yang, Haopeng Sun, Qidong You,* Xiaojin Zhang.* Novel naphtho[2,1-d]oxazole-4,5-dione as NQO1 substrates with improved aqueous solubility: Design, synthesis, and in vivo antitumor evaluation. Bioorganic & Medicinal Chemistry, 2016, 24 (5), 1006−1013.

  10.  Yonghua Lei, Tianhan Hu, Xingsen Wu, Yue Wu, Qichao Bao, Lianshan Zhang, Hua Xia, Haopeng Sun, Qidong You,* Xiaojin Zhang.* Affinity-based fluorescence polarization assay for high-throughput screening of prolyl hydroxylase 2 inhibitors. ACS Medicinal Chemistry Letters, 2015, 6 (12), 1236−1240.

  11.  Jinlei Bian, Xue Qian, Nan Wang, Tong Mu, Xiang Li, Haopeng Sun, Lianshan Zhang, Qidong You,* Xiaojin Zhang.* Palladium(II)-catalyzed CH bond activation/CC coupling/intramolecular Tsuj-Trost reaction cascade: facile access to 2H-pyranonaphthoquinones. Organic Letters, 2015, 17 (14), 3410−3413.

  12.  Yue Wu, Mingyang Hu, Li Yang, Xiang Li, Jinlei Bian, Fen Jiang, Haopeng Sun, Qidong You,* Xiaojin Zhang.* Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency. Bioorganic Medicinal Chemistry Letters, 2015, 25 (12), 2584−2588.

  13.  Jinlei Bian, Lili Xu, Bang Deng, Xue Qian, Jun Fan, Xiuwen Yang, Fang Liu, Xiaoli Xu, Xiaoke Guo, Xiang Li, Haopeng Sun, Qidong You,* Xiaojin Zhang.* Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H: quinone oxidoreductase 1 (NQO1). Bioorganic & Medicinal Chemistry Letters, 2015, 25 (6), 1244−1248.

  14.  Jinlei Bian, Bang Deng, Lili Xu, Xiaoli Xu, Nan Wang, Tianhan Hu, Zeyu Yao, Jianyao Du, Li Yang, Yonghua Lei, Xiang Li, Haopeng Sun, Xiaojin Zhang,* Qidong You.* 2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinoneoxidoreductase (NQO1). Eurpean Journal of Medicinal Chemistry, 2014, 82, 5667.

  15. Xiaojin Zhang, Xiang Li, Haopeng Sun,* Xiaojian Wang, Li Zhao, Yuan Gao, Xiaorong Liu, Shenglie Zhang, Yanyan Wang, Yingrui Yang, Su Zeng, Qinglong Guo,* Qidong You.* Garcinia xanthones as orally active antitumor agents. Journal of Medicinal Chemistry, 2013, 56 (1), 276−292.