SHI Zhihao

Source:理学院英文网  Time:2017-12-25  Page Views:106


Associate Professor of Medicinal Chemistry

School of Science China Pharmaceutical University

Phone: 86-25-86185172


Research Summary

  • New organic synthetic Methods which can efficiently construct frameworks of pharmaceutical compounds or fragments of biologically-active natural products.

  • Synthesis and structural modification of natural products with interesting bioactivity in antitumor.

  • Drug design based on in vivo metabolism mechanism and CADD.


2007     Ph.D., Applied Chemistry,

Nanjing University of Science and Technology

2004     M.S., Applied Chemistry,

Nanjing University of Science and Technology

2002      B.S., Chemical Engineering & Technology

Qilu University of Technology

Academic Experience

2015-      Associate Professor of Medicinal Chemistry, School of Science, China Pharmaceutical University

2015-2016  Department of Chemistry

Davenport Chemical Laboratories, University of Toronto


School of Science, China Pharmaceutical University

Awards and Honors


1. Juntao Ye, Zhihao Shi, Theresa Sperger, Yoshifumi Yasukawa, Cian Kingston, Franziska Schoenebeck, Mark Lautens.Remote C-H Alkylation and C-C Bond Cleavage Enabled by an in situ Generated Palladacycle.Nat. Chem.2017, 9, 361-368.

2. Khan T. Osman, Juntao Ye, Zhihao Shi, Christina Toker, Diogo Lovato, Rajiv S. Jumani, William Zuercher, Christopher D. Houston, Aled M. Edwards, Mark Lautens, Vijayaratnam Santhakumar, Raymond Hui.Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.  Bioorg. Med. Chem.2017, 25, 1672-1680.

3.Wei Zhang, Nian-Guang Li, Yu-Ping Tang, Ze-Xi Dong, Ting Gu, Wen-Yu Wu, Peng-Xuan ZhangShao-Peng Yu, Jin-Ao Duan and Zhi-Hao Shi. Investigation of 6-O-methyl-scutellarein metabolites in rats by ultra-flow liquidchromatography/quadrupole-time-of-flight mass spectrometry. Pharmaceutical Biology, , 2016

54, 10, 2158–2167

4. Ze-Xi Dong, Nian-Guang Li , Peng-Xuan Zhang , Ting Gu, Wen-Yu Wu andZhi-Hao Shi. An Efficient Chemical Synthesis of Scutellarein:An in Vivo Metabolite of Scutellarin.  Molecules 2016, 21, 263-267.

5.Zhi-Hao Shi , Nian-Guang Li , Qian-Ping Shi , Wei Zhang , Ze-Xi Dong , Yu-Ping Tang ,Peng-Xuan Zhang , Ting Gu , Wen-Yu Wu, Fang Fang , Xin-Xue , He-Min Li, Jian-Ping Yang ,Jin-Ao Duan. Synthesis of scutellarein derivatives to increase biological activityand water solubility.  Bioorg. Med. Chem. 2015, 23, 6875–6884.

6. Zhi-Hao Shi, Nian-Guang Li, Zhen-Jiang Wang , Yu-Ping Tang, Ze-Xi Dong, Wei Zhang, Peng-Xuan Zhang, Ting Gu, Wen-Yu Wu, Jian-Ping Yang,Jin-Ao Duan. Synthesis and biological evaluation of methylated scutellarein analogsbased on metabolic mechanism of scutellarin in vivo. European Journal of Medicinal Chemistry , 2015, 106 95-105.

7.Qian-Ping Shi, Zhi-Hao Shi, Nian-Guang Li, Yu-Ping Tang, Hao-Tang, Wei Zhang,Min-Zhe Shen, Ze-Xi Dong, Peng-Xuan Zhang, Jian-Ping Yang, Jin-Ao Duan. Efficient Chemical Synthesis of a Scutellarein Derivative ContainingMorpholine Ring. Letters in Organic Chemistry, 2014, 11(8),590-595.

8.Zhi-Hao Shi, Nian-Guang Li, Qian-Ping Shi, Yu-Ping Tang, Hao Tang, Min-Zhe Shen, Jin-Ao Duan. Immobilization of Chiral Manganese(III)-salen Complexes for EnantioselectiveEpoxidation of Unfunctionalised Olefins. Current Organic Synthesis, 2014, 11, 204-243.

9. Qian-Ping Shi, Zhi-Hao Shi, Nian-Guang Li, Yu-Ping Tang, Wei Li, Hao Tang, Wei-Zhang, Min-Zhe Shen and Jin-Ao Duan. Asymmetric Epoxidation of Olefins with Homogeneous Chiral (Salen) Manganese (III) Complex. Current Organic Chemistry, 2013, 17(23),2936-2970.

10.Min-Zhe Shen, Zhi-Hao Shi, Nian-Guang Li, Hao-Tang, Qian-Ping Shi, Yu-Ping Tang,Jian-Ping Yang, Jin-Ao Duan. Efficient Synthesis of 6-O-methyl-scutellarein from Scutellarin viaSelective Methylation. Letters in Organic Chemistry, 2013, 10(10), 733-737.

11.Zhi-Hao Shi, Nian-Guang Li, Qian-Ping Shi, Hao-Tang, Yu-Ping Tang, Wei-Li, Lian-Yin, Jian-Ping Yang, and Jin-Ao Duan. Design, Synthesis and Biological Evaluation of Ferulic Acid Amides as Selective Matrix Metalloproteinase Inhibitors. Medicinal Chemistry2013, 9(7), 947-954.

12.Nian-Guang Li, Min-Zhe Shen, Zhen-Jiang Wang, Yu-Ping Tang, Zhi-Hao Shi, Yi-Fan Fu,Qian-Ping Shi, Hao Tang, Jian-Ao Duan. Design, synthesis and biological evaluation of glucose-containingscutellarein derivatives as neuroprotective agents based on metabolicmechanism of scutellarin in vivo. Bioorganic&Medicinal Chemistry Letters,2013, 23(1), 102–106.

13.Zhi-Hao Shi, Nian-Guang Li, Qian-Ping Shi, Hao Tang, Yu-Ping Tang, Wei Li, Lian Yin,Jian-Ping Yang, Jin-Ao Duan. Synthesis and structureactivity relationship analysis of caffeic acidamides as selective matrix metalloproteinase inhibitors. Bioorganic&Medicinal Chemistry Letters,2013, 23(5),1206–1211.

14.Nian-Guang Li, Shu-Lin Song, Min-Zhe Shen, Yu-Ping Tang, Zhi-Hao Shi, Hao Tang, Qian-Ping Shi, Yi-Fan Fu, Jian-Ao Duan. Mannich bases of scutellarein as thrombin-inhibitors: Design, synthesis, biological activity and solubility. Bioorganic&Medicinal Chemistry,2012, 20 (24), 6919–6923.

15. Nian-Guang Li, Zhi-Hao Shi, Yu-Ping Tang, Wei-Li, Lian-Yin and Jin-Ao Duan. Discovery of Selective Small Molecular TACE Inhibitors for the Treatment ofRheumatoid Arthritis. Current Medicinal Chemistry, 2012,19(18), 2924-2956.

16.Zhi-Hao Shi, Nian-Guang Li, Yu-Ping Tang,Wei-Li, Lian-Yin, Jian-Ping Yang, Hao Tang and Jin-Ao Duan. Metabolism-based synthesis, biologic evaluation and SARs analysisof O-methylated analogs of quercetin as thrombin inhibitors. European Journal of Medicinal Chemistry, 2012, 54, 210-222.

17.Zhi-Hao Shi, Nian-Guang Li, Qian-Ping Shi, Hao-Tang, and Yu-Ping Tang. Design, Synthesis, and Preliminary Evaluation ofSubstituted Cinnamic Acid Esters as Selective MatrixMetalloproteinase Inhibitors. Drug Development Research, 2012, 73(6), 317-324.

18. Zhi-Hao Shi, Nian-Guang Li, Qian-Ping Shi, Hao Tang, Yu-Ping Tang, Wei Li,Lian Yin, Jian-Ping Yang, and Jin-Ao Duan. Design Synthesis and Biological Evaluation of CaffeicAcid Amides as Selective MMP-2 and MMP-9 Inhibitors. Drug Developmen t Research, 2012, 73(6), 343-351.