LU Tao

Source:理学院英文网  Time:2017-12-25  Page Views:14




LU, TAO

Professor of Medicinal Chemistry

Vice President of CPU

School of Sciences

Phone: 86-25-86185086

Email: lutao@cpu.edu.cn

Research Summary

The main research interests of Prof. LU are de novo drug design and chemical synthesis, computer-aided drug design, organic synthesis methodology, pharmaceutical biostatistics and computational pharmacy. He has presided over a number of national and provincial projects. His current research group has more than 10 funding from the National Natural Science Foundation of China. His group’s self-developed anti-tumor compound was transferred to Shanghai Fosun Pharma Co., Ltd. with 50 million RMB. He has published more than 100 SCI research papers and advised 13 PhD students and 85 graduate students. The group now has 11 PhD candidates and 42 graduate students.He is executive edit-in-chief of Progress in Pharmaceutical Sciences, editorial board member for Journal of China Pharmaceutical University and peer-reviewer with many SCI journals such as the Journal of Medicinal Chemistry (JMC), European Journal of Medicinal Chemistry (EJMC) and Journal of Molecular Modeling (JMM).


Education

1998-2001       Ph.D., Medicinal Chemistry, CPU

1998-2000       The University of Texas at Austin

1986-1989       M.S.,  Medicinal Chemistry, CPU

1980-1984       B.S.,   Medicinal Chemistry, CPU

Academic Experience

2013-      Vice President of CPU

2004-      Professor of Medicinal Chemistry, CPU

Publications

  1. Du Ding*, Hu Zhongyuan, Jin Jianlin, Lu Yingyan, Tang Weifang, Wang Bo, Lu Tao*. N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles. Organic Letters 2012, 14(5), 1274-1277

  2. Qingfa Zhou*, Xueping Chu, Weifang Tang, Tao Lu*, An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate. Tetrahedron 68 (2012) 4152-4158

  3. Botao Xin, Weifang Tang, Yue Wang, Guowu Lin, Haichun Liu, Yu Jiao, Yong Zhu, Haoliang Yuan, Yadong Chen*, Tao Lu*, Design, synthesis and biological evalution of β-carboline derivatives as novel inhibitors targeting B-Raf kinase. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4783–4786

  4. Wenhai Li*, Yue Wang, Tao Lu*, Facile synthesis of 1-aminoisoquinolines via the tandem reactions of 2-alkynylbenzaldoximes with isothiocyanates. Tetrahedron 68 (2012) 6843-6848

  5. Yingyan Lu, Weifang Tang, Yu Zhang, Ding Du* and Tao Lu*, N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Indolin-3-ones: Synthesis of 3,4-Dihydropyrano[3,2-b]indol-2-ones. Adv. Synth. Catal. 2013, 355, 321 – 326

  6. Chen Wang, De-Kai Ye, Yun-Yi Wang, Tao Lu* and Xing-Hua Xia*, Insights into the ‘‘free state’’ enzyme reaction kinetics in nanoconfinement. Lab on a Chip 2013, 13, 1546–1553

  7. Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Cheng Li, Tao Lu*, Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions. Mol. Divers. 2013, 17:563–571

  8. Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Yue Wang, and Tao Lu*, Phosphine-Catalyzed [3+2] Annulation of Electron-Deficient Alkynes with N-Hydroxyphthalimide: Synthesis of 3a-Hydroxyisoxazolo[3,2-a]isoindol-8 (3aH)-ones. Adv. Synth. Catal. 2013, 355, 2787-2792

  9. Yuxi Tao, Junlin Liu, Zhihui Li, Jinguan Lin, Tao Lu*, Fangrong Yan*. Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula. PLOS ONE 2013, 8(11) e78805,1-6

  10. Yanmin Zhang,Shangyan Yang,Yu Jiao,Haichun Liu,Haoliang Yuan,Shuai Lu,Ting Ran, Sihui Yao,Zhipeng Ke,Jinxing Xu,Xiao Xiong,Yadong Chen,*and Tao Lu*. An Integrated Virtual Screening Approach for VEGFR 2 Inhibitors. J. Chem. Inf. Model. 2013, 53, 31633177  

  11. Sihui Yao, Tao Lu, Zifan Zhou, Haichun Liu, Haoliang Yuan, Ting Ran, Shuai Lu, Yanmin Zhang, Zhipeng Ke, Jinxing Xu, Xiao Xiong, Yadong Chen*. An efficient multistep ligand-based virtual screening approach for GPR40 agonists. Mol. Divers. 2014, 18, 183–193

  12. Qiao-Mei Jin, Yi Lu, Jian-Lin Jin, Hao Guo, Guo-Wu Lin, Yue Wang*, Tao Lu*. Synthesis, characterization, DNA binding ability and cytotoxicity of the novel platinum(II), copper(II), cobalt(II) and nickel(II) complexes with 3-(1H-benzo[d]imidazol-2-yl)-b-carboline. Inorganica Chimica Acta 2014, 421, 91–99

  13. Haoliang Yuan,Jin Zhuang,Shihe Hu,Huifang Li, Jinxing Xu,Yaning Hu,Xiao Xiong, Yadong Chen*,Tao Lu*.Molecular Modeling of Exquisitely Selective c Met Inhibitors through 3D-QSAR and Molecular Dynamics Simulations. J. Chem. Inf. Model. 2014, 54, 25442554

  14. Zhang, Yu; Lu, Yingyan; Tang, Weifang; Lu, Tao*; Du, Ding*. Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3+2] annulations of alkynyl aldehydes with isatins. ORGANIC & BIOMOLECULAR CHEMISTRY  2014, 12(19), 3009-3015

  15. Weimin Yang, Yadong Chen, Xiang Zhou, Yazhou Gu, Wenqi Qian, Fan Zhang,

Wei Han, Tao Lu*, Weifang Tang*. Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors. European Journal of Medicinal Chemistry 2015, 89, 581596

  1. Junyu Xu, Shihe Hu, Yingyan Lu, Ying Dong, Weifang Tang, Tao Lu,,*and Ding Du,* N-Heterocyclic Carbene-Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin-3-ones with a Tetrasubstituted Carbon Stereocenter. Adv. Synth. Catal. 2015, 357, 923 –927

  2. Xin Chen,Fei-Fei Ge,Tao Lu*,and Qing-Fa Zhou*, Stereoselective Synthesis of 3 Methyleneisoindolin-1-ones via Base-2 Catalyzed Intermolecular Reactions of Electron-Deficient Alkynes 3 with N Hydroxyphthalimides. J. Org. Chem. 2015, 80, 32953301

  3. Hongmei Li, Zhen Li, Lixiang Liu, Tao Lu* and Yue Wang*, An efficient gold nanocarrier for combined chemophotodynamic therapy on tumour cells. RSC Adv., 2015, 5, 34831–34838

  4. Zhimin Zhang, Shaohua Hou, Hongli Chen, Ting Ran, Fei Jiang, Yuanyuan Bian, Dewei Zhang,Yanle Zhi, Lu Wang, Li Zhang, Hongmei Li, Yanmin Zhang, Weifang Tang, Tao Lu*,Yadong Chen*. Targeting epigenetic reader and eraser: Rational design, synthesisand in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors. Bioorganic & Medicinal Chemistry Letters 26 (2016) 2931–2935

  5. Zhimin Zhang, Li Zhang, Qingqing Chen, Tao Lu* and Qingfa Zhou*. Synthesis of functionalized tetrahydropyridazinesvia catalyst-free self [4 + 2] cycloaddition of in situgenerated 1,2-diaza-1,3-dienes. RSC Adv., 2016, 6, 61680

  6. Yanmin Zhang,Danfeng Zhang,Haozhong Tian,Yu Jiao,Zhihao Shi,Ting Ran,Haichun Liu, Shuai Lu,Anyang Xu,Xin Qiao,Jing Pan,Lingfeng Yin,Weineng Zhou,Tao Lu,* and Yadong Chen*. Identification of Covalent Binding Sites Targeting Cysteines Based on Computational Approaches. Molecular. Pharmaceutics 2016, 13(9), 3106-3118.

  7. Junyu Xu,Weiguo Zhang,Yishan Liu, Suzhen Zhu, Ming Liu, Xi Hua, Siyi Chen, Tao Lu* and Ding Du*. Formal [3+3] annulation of isatin-derived 2-bromoenals with 1,3-dicarbonyl compounds enabled by Lewis acid/N-heterocyclic carbene cooperative catalysis.  RSC Adv., 2016, 6, 18601-18606

  8. Qing-Fa Zhou,* Fei-Fei Ge,Qing-Qing Chen and Tao Lu*. Construction of pyrazolo[5,1-a]isoindol-8(3aH)-one derivatives via phosphine-catalyzed cyclization of electron-deficient alkynes and N-amino substituted phthalimide. RSC Adv., 2016, 6, 1395-1402.

  9. Qingqing Chen, Kaixuan Li, Tao Lu*, Qingfa Zhou*. Phosphine-catalyzed domino reactions of alkynyl ketones with sulfonylhydrazones: construction of diverse pyrazoloquinazoline derivatives. RSC Adv.,2016, 6(29):24792-24796.

  10. Yu Jiao, Fei Huang, Pengfei Xu, Yanmin Zhang, Shangyan Yang, Danfeng Zhang, Tao Lu* and Weifang Tang*. Discovery and Optimization of 1-(4-chloro-3-(trifluoromethyl)- phenyl)-3-(2-(amino)pyridin-3-yl)ureas as Novel KDR Kinase Inhibitors. Med Chem.2016; 12(4):328-37.

  11. Shuding Dong, Chao Fang, Weifang Tang, Tao Lu* and Ding Du*. Alkynyl Acylammoniums as Electrophilic 3C Synthons in a Formal [3+3] Annulation: Access to Functionalized 4H-Pyran-4-ones. ORGANIC LETTERS, 2016, 18(15):3882-3885

  12. Lu Wang, Gaoyuan Zhu, Weifang Tang, Tao Lu*, Ding Du*. DMAP-promoted in situ activation of bromoacetic acid as a 2-carbon synthon for facile synthesis of pyridines and fused pyridin-2-ones. Tetrahedron 2016, (72): 6510-6517

  13. Li Zhang, Beichen Zhang, Teng Jiang, Tao Lu* and Qingfa Zhou*. Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives. Organic Chemistry Frontiers 2017, 4, 119-123

  14. Wang, L.; Zhu, G.; Zhang, Q.; Duan, C.; Zhang, Y.; Zhang, Z.; Zhou, Y.; Lu, T.; Tang, W., Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance. Organic & biomolecular chemistry 2017, 15 (16), 3455-3465

  15. Wang, L.; Zhang, Q.; Zhu, G.; Zhang, Z.; Zhi, Y.; Zhang, L.; Mao, T.; Zhou, X.; Chen, Y.; Lu, T.; Tang, W., Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance. European journal of medicinal chemistry 2017, 130, 86-106.

  16. Yanle Zhi,Jianhang Huang,Na Liu,Tao Lu*,and Xiaowei Dou*. Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of β,γ Unsaturated α Ketoesters. Org. Lett. 2017, 19, 2378-2381.

  17. Hong M. Li,Zhi P. Dong,Qi Y. Wang,Li X. Liu,Bing X. Li,Xiao N. Ma,Ming S. Lin,Tao Lu,* and Yue Wang*. De Novo Computational Design for Development of a Peptide Ligand Oriented to VEGFR 3 with High Affinity and Long Circulation. Mol. Pharmaceutics 2017, 14, 2236-2244

  18. Li Zhang, Beichen Zhang, Jingyun Zhao, Yanle Zhi, Lu Wang, Tao Lu*, Yadong Chen*, Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors. European Journal of Medicinal Chemistry 138 (2017) 942-951

  19.   Zhusheng Huang, Qingqing Chen, Xiuqin Yang, Yang Liu, Li Zhang, Tao Lu* and Qingfa Zhou*. Phosphine-mediated domino reactions of phthalimidomalonates with allenoates or but-2-ynoate: facile entry into highly functionalized pyrroloisoindolinone derivatives. Org. Chem. Front. 2017, 4, 967-971

  20. Qing-Yuan Lan, Yan-Le Zhi, Hao Heng, Jie-Yi Tian, Xiao-Xing Guo, Hai-Chun Liu, Ya-Dong Chen, Tao Lu,* and Shuai Lu*. Chemical Space of FLT3 Inhibitors as the Potential Anti-AML Drugs.  Recent Patents on Anti-Cancer Drug Discovery2017,12(4), 296-322

  21. Yanmin Zhang, Lu Wang, Qing Zhang, Gaoyuan Zhu, Zhimin Zhang, Xiang Zhou, Yadong Chen, Tao Lu,* and Weifang Tang*. Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance. J.Chem.Inf.Model. 2017, 57(6), 1439−1452

  22. Chao Fang, Tao Lu,* Jindong Zhu, Kewen Sun, and Ding Du*. Formal [3 + 4] Annulation of α,β-Unsaturated Acyl Azoliums:Access to Enantioenriched N−H Free 1,5-Benzothiazepines. Org. Lett.2017, 19(13), 3470−3473

  23. Junyu Xu, Jing Cao, Chao Fang, Tao Lu* and Ding Du*. Organocatalytic C-C bond activation of cyclopropenones for ring-opening formal [3+2] cycloaddition with isatins.Org. Chem. Front.2017, 4, 560–564

  24. Weiguo Zhang, Junyu Xu, Jing Cao, Chao Fang, Jindong Zhu, Tao Lu,* Ding Du*. N-Heterocyclic carbene-mediated formal [3+3] annulation of isatin-derived a,b-unsaturated acids: Access to functionalized 3,4-spirooxindole d-lactones. Tetrahedron 2017, 73, 3249-3254

  25. Na Liu, Yanle Zhi, Jian Yao, Junhao Xing, Tao Lu,* and Xiaowei Dou*. Rhodium(I)-Catalyzed Arylation/Dehydroxylation of tert-Propargylic Alcohols Leading to Tetrasubstituted Allenes. Adv. Synth. Catal. 2017, 359,1-6