LIU Jie

Source:理学院英文网  Time:2017-12-25  Page Views:11









LIU, JIE

Associate Professor of Medicinal Chemistry

School of Sience

Phone: 86-25-86185173

Email: cpu-jill@163.com

Research Summary

Professor LIU’s research focuses on finding and designing of new molecules as potentialpharmaceutical agents including anti-cancer, anti-infectiveand cardiovascular agents.  Her underlying interests include the development of new synthetic methodologies as well as the opportunity to establish important structure-function relationships for these natural products with medicinal significance.

Education

2009     Ph.D., Medicinal Chemistry, China Pharmaceutical University

2000     B.S., Basic PharmacyChina Pharmaceutical University

Academic Experience

2015-      Associate Professor of Medicinal Chemistry,

School of Sience, CPU

2009-2015Assistantof Medicinal Chemistry,

School of Sience, CPU

Publications

  1. Chaolei Wang, Zheng Wu, Jia Wang, JieLiu,* Hequan Yao, Aijun Lin and Jinyi Xu*. An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide. Tetrahedron2015, 71, 8172-8177.

  2. Chaolei Wang, Zheng Wu, Hao Cai, Shengtao Xu, Jie Liu,* Jieyun Jiang, Hequan Yao, Xiaoming Wu, Jinyi Xu*. Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrides bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors. Bioorg. Med. Chem. Lett..2015, 25(22):5212-5216.

  3. Chaolei Wang, Guoxiang Wei, Yue Huang, Xue Yang, Hequan Yao, Jieyun Jiang,Jie Liu,*Mingqin Shen, Xiaoming Wu, Jinyi Xu*.First total synthesis of antihypertensive naturalproducts S-(+)-XJP and R-(−)-XJP. Organic&BiomolecularChemistry,2014,12(37):7338-44.

  4. Renren Baia, Xiaojing Huang, Xue Yang, Wen Hong, Yiqun Tang, Hequan Yao, Jieyun Jiang,Jie Liu, * Mingqin Shen, Xiaoming Wu,* Jinyi Xua. * Novel hybrids of natural isochroman-4-one bearing N-substitutedisopropanolamine as potential antihypertensive candidates.Bioorganic & Medicinal Chemistry,2013, 21, 2495-2502.

  5. Rong Fu, Qiujuan Wang, Qinglong Guo, Jinyi Xu, Xiaoming Wu. XJP-1 inhibits expression of NADPH oxidase subunits and activates eNOS through PI3K/Akt pathway in HUVECs activated by ox-LDL. Vascular pharmacology, 2013;58:78-86 .

  6. Renren Bai , Xue Yang , Yao Zhu , Zhiwen Zhou , Weijia Xie , Hequan Yao , Jieyun Jiang , Jie Liu* , Mingqin Shen , Xiaoming Wu, Jinyi Xu* . Novel nitric oxide-releasing isochroman-4-one derivatives: synthesis and evaluation of antihypertensive activity. Bioorg. Med. Chem. 2012(20)6848-6855.

  7. Renren Bai , Jie Liu# , Yao Zhu , Xue Yang , Chen Yang,Lingyi Kong ,Xiaobing Wang, Hengyuan Zhang , Hequan Yao , Mingqin Shen d, Xiaoming Wu,Jinyi Xu. Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. Bioorg. Med. Chem. Lett. 2012, 22, 6490-6493.