DU Ding

Source:理学院英文网  Time:2017-12-25  Page Views:11







DU, DING

Associate Professor of Organic Chemistry

Director of the Department of Organic Chemistry

School of Basic Science

Phone: 86-25-86185170

Email: 1020092081@cpu.edu.cn

Research Summary

Professor Du’s research focuses on bioactive molecule-oriented organic synthesis and asymmetric catalysis, aiming at the development of novel synthetic approaches to highly efficient construct heterocyclic motifs with promising bioactivities.

Education

2013       Visiting Scholar, Medicinal Chemistry, University of Michigan (USA)

2009       Ph.D., Organic Chemistry, Nankai University

2004       B.S., Chemistry, Jiangsu Normal University

Academic Experience

2013-      Associate Professor of Organic Chemistry, China Pharmaceutical University

2009-2013  Lecturer of Organic Chemistry, China Pharmaceutical University

Publications

  1. Chao Fang, Jing Cao, Kewen Sun, Jindong Zhu, Tao Lu,*Ding Du.* Direct and enantioselective synthesis of N-H-free 1,5-benzodiazepin-2-ones via NHC-catalyzed [3+4] annulation reaction. Chem.-A Eur. J., 2017, accepted (VIP).

  2. Jing Cao, Kewen Sun, Shuding Dong, Tao Lu, Ying Dong,*Ding Du.*Esters as Alkynyl Acyl Ammonium and Azolium Precursors: A Formal [2 + 3] Annulation with Amidomalonates via Lewis Base/Lewis Acid Cooperative Catalysis. Org. Lett.2017, 19, DOI: 10.1021/acs.orglett.7b03453.

  3. Chao Fang, Tao Lu,* Jindong Zhu, Kewen Sun, Ding Du.* Formal [3+4] annulations of , -unsaturated acyl azoliums: access to enantioenriched N-H free 1,5-benzothiazepines. Org. Lett.2017, 19, 3470. DOI: 10.1021/acs.orglett.7b01457.

  4. Jing Cao, Shuding Dong, Delu Jiang, Peiyu Zhu, Han Zhang, Rui Li, Zhanyi Li, Xuanyu Wang, Weifang Tang,* Ding Du.*-Functionalization of indolin-2-one-derived aliphatic acids for the divergent synthesis of spirooxindole -butyrolactones. J. Org. Chem.2017, 82, 4186.DOI: 10.1021/acs.joc.7b00153.

  5. Junyu Xu, Jing Cao, Chao Fang, Tao Lu,*Ding Du.* Organocatalytic C-C bond activation of cyclopropenones for ring-opening formal [3+2] cycloaddition with isatins. Org. Chem. Front.2017, 4, 560. DOI: 10.1039/c6qo00734a.

  6. Weiguo Zhang, Junyu Xu, Jing Cao, Chao Fang, Jindong Zhu, Tao Lu, Ding Du. N-Heterocyclic carbene-mediated formal [3+3] annulation ofisatin-derived , -unsaturated acids: Access to functionalized3,4-spirooxindole d-lactones. Tetrahedron, 2017, 73, 3249. DOI: 10.1016/j.tet.2017.04.055.

  7. Lu Wang, Gaoyuan Zhu, Weifang Tang, Tao Lu,* Ding Du.* DMAP-promoted in situ activation of bromoacetic acid as a 2-carbon synthon for facile synthesis of pyridines and fused pyridine-2-ones. Tetrehedron, 2016, 72, 6510.DOI: 10.1016/j.tet.2016.08.062.

  8. Shuding Dong, Chao Fang, Weifang Tang, Tao Lu,* Ding Du.* Alkynyl acylammoniums as electrophilic 3C synthons in a formal [3+3] annulations: access to functionalized 4H-pyran-4-ones. Org. Lett.2016, 18, 3882. DOI: 10.1021/acs.orglett.6b01891.

  9. Weifang Tang, Ding Du.* Access to spiro and fused indole derivatives from -unsaturated aldehydes enabled by N-heterocyclic carbene catalysis. Chem. Rec.2016, 16, 1489. DOI: 10.1002/tcr.201600018 (Invited personal account).

  10. Junyu Xu, Weiguo Zhang, Yishan Liu, Suzhen Zhu, Ming Liu, Xi Hua, Siyi Chen, Tao Lu,* Ding Du.* Formal [3 + 3] annulation of isatin-derived 2-bromoenals with 1,3-dicarbonyl compounds enabled by Lewis acid/N-heterocyclic carbene cooperative catalysis. RSC Adv.2016, 6, 18601. DOI: 10.1039/c5ra27848a.

  11. Delu Jiang, Shuding Dong, Weifang Tang, Tao Lu,* Ding Du.* N-Heterocyclic Carbene-Catalyzed Formal [3 + 2] Annulation of α-Bromoenals with 3-Aminooxindoles: A Stereoselective Synthesis of Spirooxindole γ-Butyrolactams. J. Org. Chem. 2015, 80, 11593. DOI: 10.1021/acs.joc.5b02188.

  12. Shihe Hu, Bingyang Wang,Yu Zhang,Weifang Tang,Mengyuan Fang,Tao Lu,* and Ding Du.*N-Heterocyclic Carbene-Catalyzed Annulation of Cyclic -Enamino Esters with Enals: Access to Functionalized Indolo[2,3-a]quinolizidines. Org. Biomol. Chem. 2015, 13, 4661.DOI: 10.1039/c5ob00176e.

  13. Junyu Xu, Shihe Hu, Yingyan Lu, Ying Dong, Weifang Tang, Tao Lu,* and Ding Du.*N-Heterocyclic Carbene-Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin-3-ones with a tetrasubstituted carbon stereocenter.Adv. Synth. Catal. 2015, 357, 923. DOI: 10.1002/adsc.201401070.

  14. Yu Zhang, Yingyan Lu, Weifang Tang, Tao Lu,* and Ding Du.* Cooperative N-heterocyclic carbene (NHC)/Lewis acid-mediated regioselective umpolung formal [3+2] annulations of alkynyl aldehydes with isatins. Org. Biomol. Chem.2014, 12, 3009. DOI: 10.1039/c4ob00145a.

  15. Yingyan Lu,Weifang Tang,Yu Zhang,Ding Du,* and Tao Lu.* N-Heterocyclic carbene-catalyzed annulations of enals and ynals with indolin-3-ones: synthesis of 3,4-dihydropyrano[3,2-b]indol-2-ones. Adv. Synth. Catal. 2013, 355, 321. DOI: 10.1002/adsc.201200716.

  16. Ding Du,*Zhongyuan Hu, Jianlin Jin, Yingyan Lu,Weifang Tang, Bo Wang, and Tao Lu.* N-Heterocyclic carbene-catalyzed three-component domino reaction of alkynyl aldehydes with oxindoles. Org. Lett. 2012, 14, 1274. 10.1021/ol300148f.